Sclerosing mesenteritis is a rare chronic inflammatory condition characterized by mesenteric fibrosis. There are three pathological subtypes based on level of inflammation, fat necrosis, and fibrosis: mesenteric panniculitis, mesenteric lipodystrophy, and retractile mesenteritis. The prevalence is 0.6%-1%, with the disease generally affecting middle-aged or older males. There is no known etiology, though there are a variety of potential causal factors. Clinical presentation and dual-phase abdominal CT imaging are occasionally helpful adjuncts to diagnosis, but definitive diagnosis requires surgical biopsy. Management is primarily based on anecdotal evidence, and generally consists of symptomatic treatment via surgical or medical therapy.
Alisha Gupta, Yatee A. Dave and Mihir M. Shah