Journal of Rare Disorders: Diagnosis & Therapy

Lung Cancer Location Patterns: Why Tumors Prefer Their Sites

Lung cancer is worldwide the leading non-skin cancer related cause of death and the second most diagnosed malignancy. Currently, many immunohistochemistry essays can provide precise end of line histological diagnosis, improving overall survival through efficient individualized treatment schemes. There seems to be a radiological correlation between the two basic histological tumor subtypes (adenocarcinoma and squamous cells carcinoma) and nodule site presentation in chest imaging, and although this is considered in many radiology manuals, the reasons for such presentation patterns are seldom investigated. We intend to present hypothesis and reasonable explanations for the practical consensus widely acknowledged in the manuals, considering cell types in the lung topography and histological markers in carcinogenesis which should be able to clarify whether the imaging pattern is statistically true and why certain tumor types prefer their usual sites, being adenocarcinomas preferably peripheral and squamous cell carcinoma central.

Author(s): Gabriel Gomes Vieira Ribeiro Leite* and Ana Maria Magalhaes Valle Cundari

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