Journal of Rare Disorders: Diagnosis & Therapy

Fast Growing Jaw Osteosarcoma in a 55 Year Old Woman-A Case Report

Background: Osteosarcoma is an osteoid or bone producer malignant tumour. Fast growing bones are frequently affected like metaphysical growth plates in the femur. Jaw Osteosarcoma is very rare, with an incidence of 0.7 per million, and have not been extensively evaluated.

Case presentation: A 55-years-old woman presented tooth mobility and a dental extraction was realized, with volume increase in the area next four weeks. After another four weeks of medical treatment without volume reduction biopsy was developed and histopathology report mandibular osteosarcoma. She was evaluated by oncology surgery and left hemi mandible disarticulation was planned a week later. After that week tumour progressed 70% in volume, crossing the midline, causing inability to eat and respiratory distress. It was treated initially with chemotherapy, with a 60% volume reduction and programmed for hemi mandibulectomy after chemotherapy cycles conclusion. Unfortunately the patient died after the 4th chemotherapy cycle.

Conclusion: Osteosarcoma is a very rare entity with an aggressive presentation that must be suspected and diagnosed promptly because the high growing rate could predispose bone extension, face deformation, airway compromise and dissemination. Early identification and management with chemotherapy and radiotherapy preoperatively could achieve better outcomes.

Author(s):

Brenda Ruiz Flores, Luis Angel Medina Andrade, Víctor Calao Pérez, Gabriela Hernández Hernández, Jorge Gómez Hernández, Sergio Iván Reyna Heredia, Jessica Gonzalez Noriega, Uriel Maldonado Aparicio, Lizette Blanco Aguilar and Israel Gonzalez Gonzalez

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