Journal of Rare Disorders: Diagnosis & Therapy

It has long been taken for granted that all antibody molecules rigidly adhere to their receptors on cell-surfaces. Accordingly, it has long been taken for granted that no antibody molecules mutually exchange themselves on the receptors. The length of the above concepts must be as long as that of the immunology, namely, nearly 20 decades [1]. On the other hand, existence of equilibrium among antibody molecules in the vicinity of the receptors has been established approximately 5 decades ago.

The latter concept implies that all antibody molecules loosely attach to the receptors. In other words, all antibody molecules keep repeating attaching to and detaching from their receptors. It can easily be deduced that mutual substitutions of antibody molecules take place all the time. If I dare explain the reason why contemporary immunologists won’t recognize the above reality, I would point out that they are kinds of conservative believing what their teachers teach them. Assuming that all of readers of this essay realize my relevancy, I would like to demonstrate the usefulness of the above concept. That is that both of allergic and autoimmune diseases can be completely healed because pathogenic antibodies could be substituted by non-pathogenic antibodies [2,3]. The necessary condition for the above mentioned substitution is an accumulation of non-pathogenic antibodies in the patient’s body. In order to accomplish the latter, you should inject the patient with non-specific antigens intradermally. The reason why intradermal injection is needed is because otherwise the injected non-specific antigens would be absorbed by the capillary blood vessels more quickly so that the amount of the produced non-specific antibody would be less. For this purpose, it is desirable to inject intradermally at the navel-edge [4].

References

1. Sterk AR, Ishizaka T (1982) Binding Properties of IgE Receptors on Normal Mast Cells. J Immunol 128: 838-843.
2. Okazaki K (2007) Treatment of Allergic Diseases: Application to clinical practice of a new concept of mutual substitutions of antibody molecules on the surface of mast cells. Allergy Asthma ClinImmunol 3: 36.
3. Okazaki K (2009) Therapeutic Significance of Non-Specific Antigens as Anti-Allergic and Anti-Autoimmune Agents. Pharmacometrics 76: 105-107.
4. Okazaki K (2011) Good-bye, Incurable Diseases. Universe Publisher, Indiana, USA.